Going eight separate ways

Wnt separate ways, met later

In This Issue In This Issue Wnt separate ways, met later embers of the Wnt family of secreted signaling proteins control a wide range of developmental and pathological processes, with each Wnt protein signaling through either the " canonical " or " noncanonical " pathway. Two papers in this issue (and a Comment on page 753) now bring these two pathways together, showing that the noncanonical ca...

Sending sisters their separate ways

S ister chromatids are often reluctant to separate during mitosis. Germann et al. show that a protein involved in DNA replication and repair helps eliminate lingering connections that can hold sister chromatids together (1). Sister chromatids tangle almost every time a cell enters mitosis. Unless the cell releases these links, the structures can break or fail to separate properly. Two kinds of ...

Eight Ways Videogames Generate Emotion

Many fields are interested in how videogames can generate emotion but most have a very limited conception of what emotional response includes. This paper presents a comprehensive model of emotional response to the singleplayer game based on two roles players occupy during gameplay and four different types of emotion. The emotion types are based on different ways players can interact with a vide...

Eight Ways to Build Collaborative Teams

Going both ways: immune regulation via CD1d-dependent NKT cells.

NKT cells are a unique T lymphocyte sublineage that has been implicated in the regulation of immune responses associated with a broad range of diseases, including autoimmunity, infectious diseases, and cancer. In stark contrast to both conventional T lymphocytes and other types of Tregs, NKT cells are reactive to the nonclassical class I antigen-presenting molecule CD1d, and they recognize glyc...